Zika virus infections in humans 1954–2007, confirmed by virus isolation [1]

Actualizado: 28/06/2022

_{Case number}	_Year	_Location	_Description	_{Reference/notes}
1	1954	Nigeria	10-yr-old African female with fever and headache	MacNamara 1954¹
2*	1956	Nigeria	Experimentally induced in a 34-yr-old European male, residing in Nigeria for 4 ½ months before inoculation; symptoms included headache and fever	Bearcroft 1956²
3	1964†	Uganda	28-yr-old European male, residing in Uganda for 2 ½ months before illness; with headache, rash, and fever	Simpson 1964³
4, 5, 6	1968	Nigeria	Virus isolated from 3 febrile children, aged: 10 months 2 ½ years 3 years No clinical details available	Moore 1975⁴
7, 8	1979‡	Nigeria	2 ½ yr-old boy with fever 10-yr-old boy with fever, headache, and body pains	Fagbami 1979⁵ _{40% persons tested had neutralising antibodies to Zika virus (more frequently in younger people), demonstrating high prevalence of immunity in Nigeria. Unreported cases likely misdiagnosed as malaria.}
9*	1973	Portugal	Male arbovirus laboratory worker who had been vaccinated against yellow fever 2 months before infection; with chills, fever, sweating, retro-orbital pain, and pain in the back of the neck and in the joints	Filipe 1973⁶
10-16	1981§	Indonesia	7 cases in hospitalized patients: 16-yr-old female 14-yr-old male 12-yr-old male 32-yr-old female 12-yr-old female 25-yr-old female 13-yr-old male All cases had fever; none had rash	Olson 1981⁷

* Not naturally occurring
† Infection occurred 1962-63; case published 1964
‡ Blood specimens for the 2 isolates were collected in July 1971 and May 1975; cases published in 1979
§ Cases occurred in 1977 and 1978; published 1981

¹_{MacNamara FN. Zika virus: a report on three cases of human infection during an epidemic of jaundice in Nigeria. Trans R Soc Trop Med Hyg. 1954 Mar;48(2):139–45. http://dx.doi.org/10.1016/0035-9203 [4](54)90006-1 PMID:13157159.}
²_{Bearcroft WGC. Zika virus infection experimentally induced in a human volunteer. Trans R Soc Trop Med Hyg. 1956 Sept;50(5):442-48. doi: 10.1016/0035-9203(56)90091-8.}
³_{Simpson DI. Zika virus infection in man. Trans R Soc Trop Med Hyg. 1964 Jul;58(4):335–8. http://dx.doi.org/10.1016/0035-9203 [4](64)90201-9 PMID:14175744.}
⁴_{Moore DL, Causey OR, Carey DE, Reddy S, Cooke AR, Akinkugbe FM, et al. Arthropod-borne viral infections of man in Nigeria, 1964–1970. Ann Trop Med Parasitol. 1975 Mar;69(1):49–64. PMID:1124969.}
⁵_{Fagbami AH. Zika virus infections in Nigeria: virological and seroepidemiological investigations in Oyo State. J Hyg (Lond). 1979 Oct;83(2):213–9. http://dx.doi.org/10.1017/S0022172400025997 [5] PMID:489960.}
⁶_{Filipe AR, Martins CM, Rocha H. Laboratory infection with Zika virus after vaccination against yellow fever. Arch Gesamte Virusforsch. 1973;43(4):315–9. http://dx.doi.org/10.1007/BF01556147 [6] PMID:4799154.}
⁷_{Olson JG, Ksiazek TG, Suhandiman, Triwibowo. Zika virus, a cause of fever in Central Java, Indonesia. Trans R Soc Trop Med Hyg. 1981;75(3):389–93. http://dx.doi.org/10.1016/0035- [7] 9203(81)90100-0 PMID:6275577.}