Zika virus disease: Interim case definition
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These interim case definitions have been developed for the purpose of providing global standardization for classification and reporting of Zika virus cases. WHO guidance for the surveillance of Zika virus disease is currently being developed. WHO will periodically review these interim case definitions and update them as new information becomes available.Suspected case
A person presenting with rash and/or fever and at least one of the following signs or symptoms:
- arthralgia; or
- arthritis; or
- conjunctivitis (non-purulent/hyperaemic).
Probable case
A suspected case with presence of IgM antibody against Zika virus and an epidemiological link
Confirmed case
A person with laboratory confirmation of recent Zika virus infection:
- presence of Zika virus RNA or antigen in serum or other samples (e.g. saliva, tissues, urine, whole blood); or
- IgM antibody against Zika virus positive and PRNT for Zika virus with titre ≥20 and Zika virus PRNT titre ratio ≥ 4 compared to other flaviviruses; and exclusion of other flaviviruses
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This page links all WHO information to its response on the Public Health Emergency of International Concern.Related links
Zika virus disease
Microcephaly
Guillain–Barré syndrome
Information in Portuguese