Core Indicators 2019: Health Trends in the Americas starts with a demographic overview of the Americas to demonstrate how the Region has changed over 25 years. These key demographic indicators provide valuable context to better understand the population’s characteristics and their impact on health. Brief narratives accompany the graphics to highlight important information. The second section, Trends in Health, 1995–2019, presents trend data for health indicators of interest within the topics of life expectancy, mortality, communicable and noncommunicable diseases, and risk factors. This section highlights remarkable strides in improving the population’s health within the Americas, while at the same time observing that there is still much more work ahead to ensure equitable health across the Region. The third section contains the traditional Core Indicators Data Tables updated each year for the past 25 years. The information in these tables reflects the data obtained from the 2019 round of data collection, reported from countries and territories, and UN Inter-Agency estimates. Table footnotes and notes in the appendixes provide the source and the years covered for the corresponding data.